Tutorials

  • Interface Circuits for Electro-Chemical and Molecular Sensing

    Sunday | July 28, 2024 | 10:30 - 12:00

    Accurate measurement of certain chemicals and biological substances is essential for health care and biomanufacturing. Electrochemical sensing methods are particularly useful for this purpose because they are cost-effective, can be made very small, and provide real-time data. Technologies such as pH and ion-sensitive sensors that are integrated into standard CMOS platforms (the technology used for constructing integrated circuits) have shown to be effective. For instance, large arrays of Ion-Sensitive Field-Effect Transistors (ISFET) have been instrumental in DNA sequencing. Looking ahead to advanced DNA sequencing and protein studies, innovative techniques involving nanopores are being developed for efficient, high-throughput sensing of molecules. This presentation will explore the basic principles of electrochemical sensing, with a special focus on the design of the electronic circuits involved. It will provide an overview of the latest circuit design methods used in ISFET-based sensors and will conclude by discussing specific challenges in designing circuits for nanopore-based molecular sensing.

  • CMOS Biochips: History, Opportunities and Challenges

    Sunday | July 28, 2024 | 13:30 - 15:00

    In the past 3 decades, there were many attempts to leverage integrated circuit technologies, particularly CMOS fabrication processes, to create unique biosensors capable of detecting nucleic acid molecules, proteins, and other biological and chemical analytes. While such efforts targeted a diverse set of biotechnology applications, they all shared a common motivation. CMOS biosensors (or CMOS biochips) hold the promise of delivering superior analytical accuracy alongside scalability, cost efficiency and manufacturability. Yet, the outcomes of such endeavors have been varied, and the implementation of these multidisciplinary systems has proven to be significantly more challenging and complex than initially anticipated.

  • Disruptive Soft Biosensors for Connected Healthcare

    Monday | July 29, 2024 | 13:30 - 15:00

    In the context of telehealth and internet of things (IOT), there are unprecedented needs for developing remote diagnostic tools that can monitor chemical and biological markers remotely anytime anywhere, such as via a smart phone. Such sensing devices are ideally soft and thin so that they can “bio-friendly” interface with soft biological systems. In this talk, I will present our skin-like sensing devices that can remotely monitor human’s health and cardiac organoids.